Topic: The impact of aging on adaptive and mutational landscapes in tissues

James DeGregori

    Dr. James DeGregori is a Professor in the Department of Biochemistry and Molecular Genetics (faculty since 1997) and Deputy Director of the University of Colorado Cancer Center. He has degrees from the University of Texas at Austin (B.A. Microbiology) and the Massachusetts Institute of Technology (PhD Biology), and received postdoctoral training at Duke University. He holds the Courtenay and Lucy Patten Davis Endowed Chair in Lung Cancer Research. His lab studies the evolution of cancer, in the context of their Adaptive Oncogenesis model, with a focus on how aging, smoking, Down Syndrome, and other insults influence cancer initiation and responses to therapy. Additional studies in the lab seek to identify metabolic and signaling vulnerabilities in cancer, with a focus on acute myeloid leukemias, that can be exploited for the development of more effective therapies.  For all of these studies, we leverage a variety of tools, including computational biology, genomics, metabolomics, cell biology, and biochemistry, leveraging both mouse models and human samples.

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